AICAR

Product Name:AICAR,Acadesine
Chemical Name:5-Aminoimidazole-4-carboxamide ribonucleotide
CAS NO.:2627-69-2
Molecular Formula:C9H14N4O5
Molecular Weight:258.231
Purity:99%
Appearance:White Powder
Grade:Pharmaceutical Grade

TUDCA-Tauroursodeoxycholic-Acid-Powder

Fat Loss

AICAR is a peptide, which is an intermediate within the generation of inosine monophosphate and directly related to metabolic regulation. The most important mechanism that AICAR is known for is its ability to block enzymes both in intracellular and extracellular levels, which, in turn, allows for an accelerated stimulation of glucose uptake and increase protein kinases in skeletal muscle tissue. These two functions allow for more energy conversion, which helps burn fat and also sustain output in activity. This is what scientists and athletes/bodybuilders are interested in.

AMP-activated Protein Kinase

AICAR’s principal mechanism of action is activation of AMPK (AMP-activated protein kinase.) Activating AMPK, therefore, causes the same cellular machinery (so to speak) to be turned on as if the cell were energy deprived, for example from intensive exercise, or from low caloric intake.

AICAR, at sufficient and quite substantial concentration, is effective at activating AMPK and inducing a cellular state as if exercise had been performed, or energy stores were low and fat therefore needed to be burned.

AICAR uses metabolic pathways to block certain enzymes, which allows for AMP-activated protein kinase. This can be explained to the layperson like this: once you take a substantial amount of AICAR, it tricks your body at a cellular level in to thinking that exercise has just been preformed. Since the body thinks it has just done a considerable amount of exercise, the energy cycle at the cellular level starts converting fuel sources, like fatty acids, to output the energy that was thought to have been spent during exercise. This can have a direct effect on the level of endurance activity and the sustainability of that activity. Insulin sensitivity is also noted to be one action that AICAR produces, as the body will think it just went through a series of exercises. Interestingly, in animal studies with obese mice, AICAR showed all of the peptides benefits for obese diet induced mice, yet the healthy lean mice did not reap any of the benefits of insulin sensitivity or increase in glucose uptake. That being said, the application in bodybuilding does not seem very suitable, as these mechanisms are targeted for the out-of-shape and over-weight.

Protect against ischemic Injury

Interestingly, AICAR has been shown to protect against ischemic injury. This type of injury is directly related to the restriction of blood to tissues, which can cause insufficient amounts of oxygen and glucose needed to keep the tissue alive. This can lead to thrombosis, embolisms, and vasoconstriction. AICAR can be used as a stabilizing peptide for ischemic episodes, and it can allow for proper blood flow to the myocardium (heart). This function is very interesting, as AICAR could be fundamentally used to treat the heart muscle in the aftermath of a heart attack. This might reduce the possibility for ischemic injuries. Abnormal growths of heart tissues and heart valve function have also been altered in animal studies that used the peptide AICAR, which is a downside.

 

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2,4-Dinitrophenol

Product Name:2,4-Dinitrophenol Sodium Salt
Alias:Sodium 2,4-dinitrophenate
CAS NO.:1011-73-0
Molecular Formula:C6H3N2NaO5
Molecular Weight:206.09
Purity:99%
Appearance:Orange Yellow Powder
Grade:Pharmaceutical Grade

TUDCA-Tauroursodeoxycholic-Acid-Powder

DNP is an extremely powerful and beyond controversial fat burning drug. There is no compound on earth that can burn fat at the rate of DNP; however, to say it is beyond dangerous is almost an understatement. DNP is so dangerous it can in fact kill you. No one can deny the fat loss power held by this compound is truly tremendous, but when we consider the risk there are very few if any we can recommend it too.

Effects of DNP

The effects of DNP are very simple and very straightforward, tremendous fat loss and loss of total bodyweight. So powerful, the effects of DNP can result in a full pound of body fat loss per day. Note we said a full pound of body fat, not merely weight but actual pure body fat. That is truly amazing and could easily result in twenty plus pounds of fat loss in only a few weeks, not to mention any other weight lost, i.e. water weight.

That’s it, pure fat loss, rapid and tremendous fat loss represents the full effects of DNP. The compound carries no additional traits that could be potentially desired by any human being. While sometimes labeled as a performance enhancing drug DNP carries no anabolic properties. The compound will not help the individual build muscle mass or enhance strength. The individual will not see his athletic performance enhanced; in fact, many would see it diminished as DNP can be extremely draining on energy levels. Further, due to the tremendous increase in body temperature, when we look at the side effects of DNP we will find extreme activity must be avoided when using the compound.

When looking at the effects of DNP in a performance setting, many are often curious about its fat loss power compared to other more commonly used medications. The two most commonly used fat loss aids in performance enhancement circles are undoubtedly Clenbuterol and Cytomel (T3), and both are highly effective. However, while we cannot recommend DNP and while both Clen and T3 are far safer, we cannot deny the truth. DNP is far more powerful and will lead to greater and more dramatic fat loss than both Clenbuterol and Cytomel combined. This is simply the truth; however, both Clenbuterol and Cytomel can easily be used without severe or even fatal consequences, but we cannot say the same for DNP. Absolutely, DNP can be used without it leading to your death, there are those that get away with it, but the overall risk is so great you are truly playing with fire. At Steroid.com our job is to simply give you the truth. When explaining and covering various hormones and compounds, our job is to tell you exactly what the hormones and compounds in question can do. It is not our job to insight fear, or to embellish risks that may be associated with a compound in question. Our job is to take a neutral stance and simply explain what a compound can do, the good and the bad and nothing more. But when it comes to DNP it truly is pure poison and that is not an embellished statement. Regardless, some of you will still try it and while some of you will have success others will face horrific consequences and that’s the truth.

Side Effects of DNP

There are not too many side effects of DNP use, but what does exist is tremendously damaging. Of the side effects of DNP the most concerning is death. We actually mean your heart stopping and you living no more. There have been numerous deaths reported due to DNP use over the years. Although the compound is no longer legitimately obtainable on the pharmaceutical market, death will still be a possible side effect for those who are able to find it.

Beyond death, the most common side effects of DNP use include dramatic insomnia, nausea and extreme sweating. When we refer to extreme sweating, a more accurate way to describe it would be sweating profusely. Many who have used DNP have reported ruining their mattress during periods of use due to the sweating being so intense. DNP is also well-known for causing cataracts, which in many cases ultimately leads to the individual going blind.

DNP can also have a strong, negative impact on white blood cell count by reducing the total count severely. This can have a disastrous effect on the individual’s immune system. You will be far more susceptible to viruses and infections when using DNP. It is also very common for those who use DNP to fall into a coma, which can very easily lead to an untimely death. So powerful is the compound and so great is the risk of death, reports have indicated that death can occur with only a few days of use. Talk about a risk and one that is not worth taking.

Telmisartan

Product Name:Telmisartan
Alias:Micardis
CAS NO.:144701-48-4
Molecular Formula:C33H30N4O2
Molecular Weight:514.62
Purity:99%
Appearance:White Powder
Grade:Pharmaceutical Grade

LGD-3033

Telmisartan (Micardis) is an oral prescription medication most commonly used to treat hypertension, including mild hypertension where blood pressure is only moderately elevated or borderline. If choosing to self-medicate for mild hypertension or borderline high blood pressure, telmisartan is an excellent or even best choice.

As elevated blood pressure is often an undesired side effect of anabolic steroid cycles and can even limit use of androgens, this use of telmisartan is already enough to make the drug of value to many.

However, telmisartan also has an entirely different category of use, due to having quite a number of other interesting properties which can be valuable in some instances.

Benefits can include improvement to fat loss, endurance, insulin sensitivity, reduction of risk of atherosclerosis, stroke, and of heart attack, and possible benefit to brain health. In some cases mood or energy can be improved as well.

When to use telmisartan

If blood pressure needs to be moderated, I’d certainly consider using telmisartan. If there is no such need, factors that could suggest its use include interest in reducing visceral fat, of improving impaired insulin sensitivity, of reducing risk of atherosclerosis, or depending on personal interest, of possibly improving brain health and function.

Reasons not to use telmisartan could include unwillingness to accept the risk of possible side effects, or unwillingness to shift the balance of fat loss towards visceral fat loss versus subcutaneous fat loss. In general, if dieting and training achieve only the same bodyfat percentage despite the positive effects of telmisartan, appearance could be smoother due to the same amount of bodyfat being present but with less of it stored as unhealthful visceral fat. On the other hand, if taking advantage of improved loss of visceral fat with telmisartan to achieve a lower bodyfat percentage, then there’s no smoothness penalty. However, when aiming for contest condition there’s a certain amount of fat that the body must retain: theoretically, reducing visceral fat in this case might force retention of a greater amount of subcutaneous fat. So I wouldn’t advise telmisartan use in the last few weeks before a bodybuilding contest.

How to use telmisartan

To reduce risk of atherosclerosis, cardiovascular disease, or stroke where risk is only moderate in the first place, I suggest a dose from 20 to 40 mg taken orally once per day. Dosing would be the same where the interest is slowing loss of brain function with age, or potentially improving brain function.

For possible improvement in fat loss, particularly of visceral fat, or improvement of endurance I suggest dosing of 80-160 mg/day. Starting dose, however, generally should be only 40 mg/day until tolerance is assessed.

While it’s not required and telmisartan users in general do not do so, when using this drug I suggest supplementing with oleuropein 200-400 mg/day and Vitamin D 5000 IU/day. These are to reduce or perhaps eliminate two activities of telmisartan that I would not consider desirable for physique or performance enhancement, though they add to its medical use.

Telmisartan should not be used in combination with a diuretic, and I would avoid allowing severe dehydration while using this drug.

Blood pressure should be monitored while using telmisartan. Typically, any decrease of blood pressure is simply to healthful levels or more-nearly healthful levels, and those who do not have high blood pressure see no decrease with telmisartan. Still, there can be exceptions, so this should be watched.

Lastly, I would cycle telmisartan use rather than use it continuously. There’s no proof of what cycling method might be optimal, but for example I’d suggest being “off” about as many weeks per year as “on” as a minimum. This is not because of proven problem, but simply because I expect the benefits can be fully or nearly fully realized with this amount of use, and where any of the changes to gene expression or receptor blocking might be adverse in the individual case rather than beneficial, this will then be no more than half the time.

Synephrine

Product Name:Synephrine
Alias:Oxedrine
CAS NO:94-07-5,582-84-3
EINECS:202-300-9
Formula:C9H13NO2
Molecular Weight:167.205
Assay:98%
Appearance:Light yellow to off-white fine powder
Grade:Pharmaceutical Grade
Usage:used for rising blood pressure
Product Resource: Extracted from the dried immature fruit of Citrus aurantium L.

Andarine-S-4-.jpg

Application scope

Synephrine is one of the adrenergic amines that stimulates the beta-3 receptors with minimal impact on the other receptor sites. This functions to increase the metabolic rate without affecting heart rate or blood pressure. Synephrine releases adrenaline and noradrenaline only in the beta-3 receptor sites (mostly adipose tissue and the liver). Stimulation of the beta-3 receptor sites elicits the breakdown of lipolysis (fat).Synephrine is used to activate the adrenaline system without the stimulatory effect posed by ephedra-based products.

In application of traditional Chinese medical science,Synephrine is used to dispel bloating and a lump in the abdomen and phlegm, and to cureedema, constipation, gastroptosis, prolapse of uterus and rectocele.Anti- tumour, prevent osteoporosis, reduce cholesterin and protect heart.Nerve protection and prevent diseases of degeneration ofnerve.Relieve menopausal symptoms of women, improve bone metabolism and protect cardiovascular system, etc.

Fat Loss

Synephrine is a stimulant, similar to caffeine and ephedrine. It is thought to have similar effects in terms of providing an energy boost, suppressing appetite and increasing metabolic rate leading to the burning or more calories. It is used as a safer alternative to Ma Huang, synephrine is theorized to stimulate fat metabolism without the negative cardiovascular side effects experienced by some people with Ma Huang.

The most likely explanation for weight loss effects attributed to citrus aurantium (synephrine) supplements is the stimulant like effects of the alkaloids. Although this effect is likely to be somewhat less dramatic that effects induced by Ma Huang (ephedra – also known as Sida Cordifolia), users can expect variable effects including reduced appetite and heightened feelings of energy (similar to caffeine)… both of which are likely to result in weight loss.

Synephrine Dosage

Take about 5-20mg of synephrine two to three times per day, having one of those doses 30-60 minutes prior to workouts.

Calcium Pyruvate

Product Name:Calcium pyruvate
Synonym: Pyruvic acid Calcium salt; Pyruvic acid calcium
CAS: 52009-14-0
MF: C6H6CaO6
MW: 214.19
EINECS: 257-599-9
Appearance: White to light yellow powder
Purity: 99%
Grade:Pharmaceutical Grade

LGD-3033

Fat Loss

Calcium pyruvate can enhance exercise endurance, increase cell energy, prevent or reduce due to too much caused by the consumption of fat and increase in body weight, heart, muscle inhibition efficiency, reduce the high fat fed cholesterol.

Pyruvate is a 3-carbon energy intermediate produced in cells from glucose, en route to creating ATP (the main energy currency of working cells). Pyruvate supplementation has been proposed to enhance work output and weight loss by providing more efficient energy that bypasses the ability of the body to store glucose as body fat.

Many claim that calcium pyruvate can help with weight and/or fat loss. In theory, since it is the raw material for cellular respiration, supplementing with calcium pyruvate should increase the amount of energy burned, therefore allowing for more fat burning. The question is whether this is actually the case. A study done by Dr. Ronald Stanko at the University of Pittsburgh concluded that calcium pyruvate does have this fat burning effect. Obese women were put on a 1,000-calorie diet for 21 days during this study. The group receiving calcium pyruvate experienced 48 percent higher fat loss, amounting to 3.2 extra pounds. However, very large doses of 30 grams per day were used to elicit this result. The common recommendation of 5 grams per day may not be enough to produce similar results. The expense of high dosage supplementation with calcium pyruvate may be too expensive for some. Diet-and-Health.net discounts the research, claiming that there is still no solid evidence for weight loss benefits.

Application

1. Calcium pyruvate as dietary supplements, has accelerated fat consumption, reduce weight, enhance human endurance, improve the efficacy of athletic performance etc.

2. A special protective effect on the heart, can enhance the effectiveness of the heart muscle, causing a reduction in heart disease or cardiac ischemia injury.

3. At the same time, calcium pyruvate engulfed in a free radicals and inhibit the formation of free radicals and other significant effects.

4.Some suggest that other potential benefits of calcium pyruvate supplementation may include antioxidant activity for antiaging, lower blood pressure and cholesterol, increased glyogen storage and utilization,

Effective Dose

The effect of calcium pyruvate may be dependent on the dose, and if you’re dieting when you take it. In the “American Journal of Clinical Nutrition” study, participants who took 30 grams of pyruvate, 16 grams of which was calcium pyruvate, were on restricted diets. Pyruvate accounted for 13 percent of the participants’ diets. In the study published in “Nutrition,” which did not find significant effects for pyruvate, participants maintained their normal diets and took 5 grams of calcium pyruvate twice a day.

Side Effect

However, side effects, such as diarrhea, bloating, gas and increased bowel movements have been recorded. For those with heart disease, be sure to get calcium pyruvate, as compounds stabilized with sodium may increase blood pressure to dangerous levels.

Benzocaine

Product name: Benzocaine;Anesthesin;Parathesin;Auralgan Otic;Ethyl aminobenzoate
Alias: Americaine,Ethyl 4-aminobenzoate
CAS register number:94-09-7
Assay:99.5%
EINECS:202-303-5
Molecular formula:C9H11NO2
Molecular weight:165.19
Appearance: White crystalline powder
Grade : Pharmaceutical Grade
Usage:Diet Supplements,Appetite suppressants

LGD-3033

Weight Loss

New treads in human dieting and medical products have previously commonly used benzocaine as the primary ingredient the products. Recently its been found in appetite-suppressants, presumably to reduce the sense of taste, resulting in a reduction eating.

Benzocaine is used as a key ingredient in numerous pharmaceuticals:Over the counter throat lozenges such as Cepacol.Some glycerol-based ear medications for use in removing excess wax as well as relieving ear conditions such as otitis media and swimmers ear.Some previous diet products such as Ayds.Some condoms designed to prevent premature ejaculation. Benzocaine largely inhibits sensitivity on the penis, and can allow for an erection to be maintained longer (in a continuous act) by delaying ejaculation. Conversely, an erection will also fade faster if stimulus is interrupted.Benzocaine mucoadhesive patches have been used in reducing orthodontic pain.

Well, basically Benzocaine is intended to numb the taste buds and help reduce appetite. This way you eat less food, which means fewer calories. Over time, this can lead to weight reduction. Considering the previous popularity of Ayds diet candy, Benzocaine clearly helped some people lose weight.

 

 

Lorcaserin hydrochloride

Product Name: Lorcaserin HCl
CAS: 846589-98-8
MF: C11H14ClNClH
MW: 232.1525
Appearance:White Powder
Grade:Pharmaceutical Grade

TUDCA-Tauroursodeoxycholic-Acid-Powder

Lorcaserin, currently marketed under the trade name Belviq and previously Lorqess during development,is a weight-loss drug developed by Arena Pharmaceuticals. It has serotonergic properties and acts as an anorectic.

Lorcaserin is used long term for weight loss in those who are obese.BELVIQ is an FDA-approved prescription weight-loss medication that, when used with diet and exercise, can help some overweight adults with a weight-related medical problem, or obese adults, lose weight and keep it off.

Lorcaserin VS Orlistat

Lorcaserin is a selective 5-HT2C receptor agonist,and in vitro testing of the drug showed reasonable selectivity for 5-HT2C over other related targets. 5-HT2C receptors are located almost exclusively in the brain. The activation of 5-HT2C receptors in the hypothalamus is supposed to activate proopiomelanocortin (POMC) production and consequently promote weight loss through satiety.The safety and effectiveness was tested in the 3 clinical trials which nearly 8000 overweight or obese participants were involved.

Orlistat works by inhibiting gastric and pancreatic lipases, the enzymes that break down triglycerides in the intestine. When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and instead are excreted unchanged. Only trace amounts of orlistat are absorbed systemically; the primary effect is local lipase inhibition within the GI tract after an oral dose. The primary route of elimination is through the feces. But for a part of stubborn obesity who get good appetite, the treatment effect is not ideal.